Pipeline

Merrimack currently has six oncology therapeutics in clinical development, multiple product candidates in preclinical development and an active Systems Biology-driven discovery effort. 

Regimens

Merrimack is applying its novel diagnostics and therapeutics in the clinic through the development of regimens for specific tumor types. These regimens couple diagnostic and therapeutic combinations that are targeted to improve patient outcomes.  Click below to learn more about our regimens. 

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Explore our Publications

Browse our library to explore published research papers, clincal data, conference presentations and featured scientific news and events related to Merrimack.

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  • MM-121 (Signaling Inhibitor)

    • Indication:
    • Description:
    • Target
    • NSCLC, Breast Cancer, Ovarian Cancer
    • Monoclonal Antibody
    • ErbB3

    MM-121/SAR256212 is a fully human monocolonal antibody that targets the HER3 receptor. Merrimack’s Network Biology approach identified HER3 as a critical tumorigenic node in several types of cancer.

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  • MM-111 (Signaling Inhibitor)

    • Indication:
    • Description:
    • Target
    • Gastric cancer (2nd line)
    • Bi-specific antibody
    • ErbB3 & ErbB2

    MM-111 is a first-in-class bispecific antibody that has been shown in preclinical studies to bind with both specificity and avidity to HER2 and HER3 expressing tumor cells. The HER2 arm is responsible for initial tumor cell targeting and docking, while the therapeutic HER3 arm is designed to block heregulin-induced cell signaling.

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  • MM-151 (Signaling Inhibitor)

    • Indication:
    • Description:
    • Target
    • Refractory advanced solid tumors
    • Oligoclonal Antibody
    • EGFR

    MM-151 is an oligoclonal therapeutic consisting of a mixture of three fully human monocolonal antibodies designed to bind and inhibit signaling of the Epidermal Growth Factor Receptor (EGFR).

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  • MM-141 (Signaling Inhibitor)

    • Indication:
    • Description:
    • Target
    • Cancer
    • Bispecific tetravalent antibody
    • IGF-1R & ErbB3

    MM-141 is a monoclonal antibody that acts as a tetravalent inhibitor of PI3K/AKT/mTOR, which is a major pro-survival pathway tumor cells use as a resistance mechanism to anti-cancer therapies.

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  • MM-131 (Signaling Inhibitor)

    • Indication:
    • Description:
    • Target
    • Cancer
    • Multispecific Antibody
    • Undisclosed

    MM-131 is currently in preclinical development.

  • MM-398 (Nanotherapeutic)

    • Target Indication:
    • Description:
    • Design:
    • Pancreatic Cancer (2nd line, 2 indications), Colorectal Cancer, Glioma
    • Nanotherapeutic
    • Encapsulated irinotecan

    MM-398 is a nanotherapeutic consisting of the chemotherapeutic irinotecan, encapsulated in a liposomal sphere. MM-398 is an investigational agent, designed to rely on the blood flow of the tumor to direct the therapy to the site of the cancer and minimize exposure to non-target cells.

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  • MM-302 (Nanotherapeutic)

    • Target Indication:
    • Description:
    • Design:
    • Advanced HER2+ breast cancer
    • Antibody targeted nanotherapeutic
    • Her2-targeted encapsulated doxorubicin

    MM-302 is a HER2-targeted nanotherapeutic consisting of the chemotherapeutic doxorubicin, encapsulated in a liposomal sphere. Doxorubicin has been a standard therapy for the treatment of breast cancer for more than 30 years.

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  • MM-310 (Nanotherapeutic)

    • Indication:
    • Description:
    • Target
    • Cancer
    • Antibody targeted nanotherapeutic
    • Undisclosed

    MM-310 is currently in preclinical development.

  • MM-121
  • MM-111
  • MM-151
  • MM-141
  • MM-131
  • MM-398
  • MM-302
  • MM-310